Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RHOA is a modulator of the cholesterol-lowering effects of statin.

PLoS genetics - 1 Jan 2012

Medina Marisa W, Theusch Elizabeth, Naidoo Devesh, Bauzon Frederick, Stevens Kristen, Mangravite Lara M, Kuang Yu-Lin, Krauss Ronald M

Abstract excerpt

Although statin drugs are generally efficacious for lowering plasma LDL-cholesterol levels, there is considerable variability in response. To identify candidate genes that may contribute to this variation, we used an unbiased genome-wide filter approach that was applied to 10,149 genes expressed in immortalized lymphoblastoid cell lines (LCLs) derived from 480 participants of the Cholesterol and Pharmacogenomics...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Pharmacological
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol

Share to Clinical Trials as Topic

Share to Lipid Metabolism

Share to Pravastatin

Share to rhoA GTP-Binding Protein

Share to Simvastatin

Source

Open in PubMed Open full text

Identifiers

PMID: 23166513
DOI: 10.1371/journal.pgen.1003058
PMCID: PMC3499361

Genes

RHOA
APOB
HMGCR
CRP
LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RHOA is a modulator of the cholesterol-lowering effects of statin.PMID 23166513Read ↗

HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism.Semantic proximity Read ↗

RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function.Semantic proximity Read ↗

Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin.Semantic proximity Read ↗

Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatinSemantic proximity Read ↗

The role of HMGCR alternative splicing in statin efficacy.Semantic proximity Read ↗

Statins and Cardiovascular Diseases: From Cholesterol Lowering to PleiotropySemantic proximity Read ↗

Genome-wide analysis of LXRα activation reveals new transcriptional networks in human atherosclerotic foam cells.Semantic proximity Read ↗

Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin responseSemantic proximity Read ↗

Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.Semantic proximity Read ↗

Genetic variants modulate gene expression statin response in human lymphoblastoid cell linesSemantic proximity Read ↗

Genome-wide association of lipid-lowering response to statins in combined study populations.Semantic proximity Read ↗

Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.