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Article

HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism.

Human molecular genetics - 15 Jan 2014

Yu Chi-Yi, Theusch Elizabeth, Lo Kathleen, Mangravite Lara M, Naidoo Devesh, Kutilova Mariya, Medina Marisa W

Abstract excerpt

3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) encodes the rate-limiting enzyme in the cholesterol biosynthesis pathway and is inhibited by statins, a class of cholesterol-lowering drugs. Expression of an alternatively spliced HMGCR transcript lacking exon 13, HMGCR13(-), has been implicated in the variation of plasma LDL-cholesterol (LDL-C) and is the single most informative molecular marker of LDL-C...

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Source

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Identifiers

PMID: 24001602
DOI: 10.1093/hmg/ddt422
PMCID: PMC3869353

Genes

HNRNPA1
HMGCR
APOB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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