Article
Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1.
The Journal of biological chemistry - 4 Jan 2013
Scilabra Simone D, Troeberg Linda, Yamamoto Kazuhiro, Emonard Hervé, Thøgersen Ida, Enghild Jan J, Strickland Dudley K, Nagase Hideaki
Abstract excerpt
Tissue inhibitor of metalloproteinases-3 (TIMP-3) plays a key role in regulating extracellular matrix turnover by inhibiting matrix metalloproteinases (MMPs), adamalysins (ADAMs), and adamalysins with thrombospondin motifs (ADAMTSs). We demonstrate that levels of this physiologically important inhibitor can be regulated post-translationally by endocytosis. TIMP-3 was endocytosed and degraded by a number of cell...
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