Localization of the functional domains of human tissue inhibitor of metalloproteinases-3 and the effects of a Sorsby's fundus dystrophy mutation.

doi:10.1074/jbc.273.27.16778

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Article

Localization of the functional domains of human tissue inhibitor of metalloproteinases-3 and the effects of a Sorsby's fundus dystrophy mutation.

The Journal of biological chemistry - 3 Jul 1998

Langton K P, Barker M D, McKie N

Abstract excerpt

A transient COS-7 cell expression system was used to investigate the functional domain arrangement of tissue inhibitor of metalloproteinases-3 (TIMP-3), specifically to assess the contribution of the amino- and carboxyl-terminal domains of the molecule to its matrix metalloproteinase (MMP) inhibi...

Topics

Animals
COS Cells
Humans
Macular Degeneration
Mutation
Recombinant Fusion Proteins
Tissue Inhibitor of Metalloproteinase-2
Tissue Inhibitor of Metalloproteinase-3
Transfection

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