Article
Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor-alpha-converting enzyme.
The Journal of biological chemistry - 23 Sept 2005
Wei Shuo, Kashiwagi Masahide, Kota Smitha, Xie Zhihong, Nagase Hideaki, Brew Keith
Abstract excerpt
Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a dual inhibitor of the matrix metalloproteinases (MMPs) and some adamalysins, two families of extracellular and cell surface metalloproteinases that function in extracellular matrix turnover and the shedding of cell surface proteins. The mechan...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.