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Article

The CYP 3A4*22allele affects the predictive value of a pharmacogenetic algorithm predicting tacrolimus predose concentrations

19 Nov 2012

Abstract excerpt

The cytochrome P450 (CYP) 3A4*22 allelic status influences the pharmacokinetics of tacrolimus independently of an individual's CYP3A5 genotype 1, 2. In their recent publication, Passey et al. 3 described an algorithm that predicts tacrolimus apparent clearance (CL/F) by taking into account the age and CYP3A5 genotype of a patient, time after kidney transplantation, whether the transplantation was performed at a...

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PMID: 23163400
DOI: 10.1111/bcp.12038

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The CYP 3A4*22allele affects the predictive value of a pharmacogenetic algorithm predicting tacrolimus predose concentrationsPMID 23163400Read ↗

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