Article
Introducing a fast and simple PCR-RFLP analysis for the detection of mutant thiopurine S-methyltransferase alleles TPMT*3A and TPMT*3C.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Apr 2006
Oender K, Lanschuetzer C M, Laimer M, Klausegger A, Paulweber B, Kofler B, Hintner H, Bauer J W
Abstract excerpt
BACKGROUND: Azathioprine, in combination with corticosteroids, is the first-line therapy of severe forms of pemphigus vulgaris. Patients with an impaired thiopurine S-methyltransferase (TPMT) activity are at risk of developing severe myelo-suppression upon treatment with thiopurines such as azath...
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