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Article

High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC.

Clinical chemistry - 1 Mar 2001

Schaeffeler E, Lang T, Zanger U M, Eichelbaum M, Schwab M

Abstract excerpt

BACKGROUND: The thiopurine S:-methyltransferase (TPMT) genetic polymorphism has a significant clinical impact on the toxicity of thiopurine drugs, which are used in the treatment of leukemia and as immunosuppressants. To date, 10 mutant alleles are known that are associated with intermediate or l...

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Share to Antimetabolites, Antineoplastic
Share to Chromatography, High Pressure Liquid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mercaptopurine

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Share to Polymorphism, Restriction Fragment Length

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Source

Identifiers

PMID: 11238310

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11238310-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC.PMID 11238310Read ↗

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Introducing a fast and simple PCR-RFLP analysis for the detection of mutant thiopurine S-methyltransferase alleles TPMT*3A and TPMT*3C.Semantic proximity Read ↗

Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods.Semantic proximity Read ↗

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Genetic Polymorphism of Thiopurine S-Methyltransferase: Molecular Mechanisms and Clinical ImportanceSemantic proximity Read ↗

Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants.Semantic proximity Read ↗

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