Article
Thiopurine S-methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs.
European journal of clinical pharmacology - 1 Mar 2004
Wusk Barbara, Kullak-Ublick G A, Rammert C, von Eckardstein A, Fried M, Rentsch K M
Abstract excerpt
OBJECTIVE: More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs. Therefore, screening for TPMT polymorphisms in a patient prior to prescribing these agents is recommended. The goal of this study was to determine a cut-off concentration of the TPMT activity assay...
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