Article
Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants.
Pharmacogenetics - 1 Jul 2004
Schaeffeler Elke, Fischer Christine, Brockmeier Dierk, Wernet Dorothee, Moerike Klaus, Eichelbaum Michel, Zanger Ulrich M, Schwab Matthias
Abstract excerpt
The thiopurine S-methyltransferase (TPMT) genetic polymorphism has a significant clinical impact on the toxicity of thiopurine drugs. It has been proposed that the identification of patients who are at high risk for developing toxicity on the basis of genotyping could be used to individualize drug treatment. In the present study, phenotype-genotype correlation of 1214 healthy blood donors was investigated to...
Topics
- Adolescent
- Adult
- Aged
- Erythrocytes
- Female
- Genetic Variation
- Genotype
- Germany
- Humans
- Kinetics
- Methyltransferases
- Middle Aged
- Phenotype
- Sex Characteristics