PAK3 mutation in nonsyndromic X-linked mental retardation.

doi:10.1038/1675

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

PAK3 mutation in nonsyndromic X-linked mental retardation.

Nature genetics - 1 Sept 1998

Allen K M, Gleeson J G, Bagrodia S, Partington M W, MacMillan J C, Cerione R A, Mulley J C, Walsh C A

Abstract excerpt

Nonsyndromic X-linked mental retardation (MRX) syndromes are clinically homogeneous but genetically heterogeneous disorders, whose genetic bases are largely unknown. Affected individuals in a multiplex pedigree with MRX (MRX30), previously mapped to Xq22, show a point mutation in the PAK3 (p21-ac...

Topics

Animals
Base Sequence
Brain
COS Cells
Cloning, Molecular
Female
Fluorescent Antibody Technique, Indirect
Humans
Intellectual Disability
Male
Mice
Molecular Sequence Data
Mutation
Pedigree
Protein Serine-Threonine Kinases
Rats
Recombinant Proteins
Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 9731525
DOI: 10.1038/1675

Genes

PAK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9731525-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics