A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype–genotype association study

doi:10.1016/s1473-3099(16)30415-7

Article

A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype–genotype association study

3 Nov 2016

Abstract excerpt

BACKGROUND: Western Cambodia is the epicentre of Plasmodium falciparum multidrug resistance and is facing high rates of dihydroartemisinin-piperaquine treatment failures. Genetic tools to detect the multidrug-resistant parasites are needed. Artemisinin resistance can be tracked using the K13 molecular marker, but no marker exists for piperaquine resistance. We aimed to identify genetic markers of piperaquine...

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