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Article

Cardiac remodeling caused by transgenic overexpression of a corn Rac gene.

American journal of physiology. Heart and circulatory physiology - 1 Sept 2011

Elnakish Mohammad T, Awad Mohamed M, Hassona Mohamed D H, Alhaj Mazin A, Kulkarni Aditi, Citro Lucas A, Sayyid Muzzammil, Abouelnaga Zeinb A, El-Sayed Osama, Kuppusamy Periannan, Moldovan Leni, Khan Mahmood, Hassanain Hamdy H

Abstract excerpt

Rac1-GTPase activation plays a key role in the development and progression of cardiac remodeling. Therefore, we engineered a transgenic mouse model by overexpressing cDNA of a constitutively active form of Zea maize Rac gene (ZmRacD) specifically in the hearts of FVB/N mice. Echocardiography and MRI analyses showed cardiac hypertrophy in old transgenic mice, as evidenced by increased left ventricular (LV) mass...

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Source

Identifiers

PMID: 21622832
DOI: 10.1152/ajpheart.00807.2010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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