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Article

Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA damage sensitivity through the translesion synthesis pathway.

The Journal of biological chemistry - 5 Nov 2010

Lévesque Nancy, Leung Grace P, Fok Alexandra K, Schmidt Thorsten I, Kobor Michael S

Abstract excerpt

Genomic integrity is maintained by the coordinated interaction of many DNA damage response pathways, including checkpoints, DNA repair processes, and cell cycle restart. In Saccharomyces cerevisiae, the BRCA1 C-terminal domain-containing protein Rtt107/Esc4 is required for restart of DNA replicat...

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Source

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Identifiers

PMID: 20810656
DOI: 10.1074/jbc.M110.116855
PMCID: PMC2966125

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20810656-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA damage sensitivity through the translesion synthesis pathway.PMID 20810656Read ↗

Rtt107 BRCT domains act as a targeting module in the DNA damage response.Semantic proximity Read ↗

Rtt107 is required for recruitment of the SMC5/6 complex to DNA double strand breaks.Semantic proximity Read ↗

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Regulation of rtt107 recruitment to stalled DNA replication forks by the cullin rtt101 and the rtt109 acetyltransferase.Semantic proximity Read ↗

Rtt107 cooperates with Rad55 to limit specific types of genome instability in Saccharomyces cerevisiae.Semantic proximity Read ↗

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