Article
Role of Cryptococcus neoformans Rho1 GTPases in the PKC1 signaling pathway in response to thermal stress.
Eukaryotic cell - 1 Jan 2013
Lam Woei C, Gerik Kimberly J, Lodge Jennifer K
Abstract excerpt
To initiate and establish infection in mammals, the opportunistic fungal pathogen Cryptococcus neoformans must survive and thrive upon subjection to host temperature. Primary maintenance of cell integrity is controlled through the protein kinase C1 (PKC1) signaling pathway, which is regulated by a Rho1 GTPase in Saccharomyces cerevisiae. We identified three C. neoformans Rho GTPases, Rho1, Rho10, and Rho11, and...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Cell Wall
- Conserved Sequence
- Cryptococcus neoformans
- Fungal Proteins
- Gene Knockout Techniques
- Heat-Shock Response
- MAP Kinase Signaling System
- Melanins
- Microbial Viability
- Mitogen-Activated Protein Kinases
- Molecular Sequence Data