Article
Ras1 acts through duplicated Cdc42 and Rac proteins to regulate morphogenesis and pathogenesis in the human fungal pathogen Cryptococcus neoformans.
PLoS genetics - 1 Jan 2013
Ballou Elizabeth Ripley, Kozubowski Lukasz, Nichols Connie B, Alspaugh J Andrew
Abstract excerpt
Proliferation and morphogenesis in eukaryotic cells depend on the concerted activity of Rho-type GTPases, including Ras, Cdc42, and Rac. The sexually dimorphic fungus Cryptococcus neoformans, which encodes paralogous, non-essential copies of all three, provides a unique model in which to examine the interactions of these conserved proteins. Previously, we demonstrated that RAS1 mediates C. neoformans virulence by...
Topics
- Cryptococcus neoformans
- Cytokinesis
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Humans
- Morphogenesis
- Mutation
- Signal Transduction
- cdc42 GTP-Binding Protein
- rac GTP-Binding Proteins