Impact of Protein Palmitoylation on the Virulence Potential of Cryptococcus neoformans.

doi:10.1128/EC.00010-15

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Article

Impact of Protein Palmitoylation on the Virulence Potential of Cryptococcus neoformans.

Eukaryotic cell - 1 Jul 2015

Nichols Connie B, Ost Kyla S, Grogan Dayton P, Pianalto Kaila, Hasan Shirin, Alspaugh J Andrew

Abstract excerpt

The localization and specialized function of Ras-like proteins are largely determined by posttranslational processing events. In a highly regulated process, palmitoyl groups may be added to C-terminal cysteine residues, targeting these proteins to specific membranes. In the human fungal pathogen Cryptococcus neoformans, Ras1 protein palmitoylation is essential for growth at high temperature but is dispensable for...

Topics

Acetyltransferases
Animals
Blotting, Western
Cell Membrane
Cryptococcosis
Cryptococcus neoformans
Female
Fungal Proteins
Gene Expression Regulation, Fungal
Homologous Recombination
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipoylation

Mice

Mice, Inbred A

Mutation

Signal Transduction

Virulence

ras Proteins

Source

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Identifiers

PMID: 25862155
DOI: 10.1128/EC.00010-15
PMCID: PMC4486677

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