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Article

Molecular mechanisms of hypoxic responses via unique roles of Ras1, Cdc24 and Ptp3 in a human fungal pathogen Cryptococcus neoformans.

PLoS genetics - 1 Apr 2014

Chang Yun C, Khanal Lamichhane Ami, Garraffo H Martin, Walter Peter J, Leerkes Maarten, Kwon-Chung Kyung J

Abstract excerpt

Cryptococcus neoformans encounters a low oxygen environment when it enters the human host. Here, we show that the conserved Ras1 (a small GTPase) and Cdc24 (the guanine nucleotide exchange factor for Cdc42) play an essential role in cryptococcal growth in hypoxia. Suppressor studies indicate that PTP3 functions epistatically downstream of both RAS1 and CDC24 in regulating hypoxic growth. Ptp3 shares sequence...

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Identifiers

PMID: 24762475
DOI: 10.1371/journal.pgen.1004292
PMCID: PMC3998916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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