Article
A Rac homolog functions downstream of Ras1 to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans.
Eukaryotic cell - 1 Jun 2005
Vallim Marcelo A, Nichols Connie B, Fernandes Larissa, Cramer Kari L, Alspaugh J Andrew
Abstract excerpt
The Cryptococcus neoformans Ras1 protein serves as a central regulator for several signaling pathways. Ras1 controls the induction of the mating pheromone response cascade as well as a distinct signaling pathway that allows this pathogenic fungus to grow at human physiological temperature. To characterize elements of the Ras1-dependent high-temperature growth pathway, we performed a multicopy suppressor screen,...
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