Article
Pneumocystis carinii BCK1 functions in a mitogen-activated protein kinase cascade regulating fungal cell-wall assembly.
FEBS letters - 31 Jul 2003
Thomas Charles F, Vohra Pawan K, Park John G, Puri Veenu, Limper Andrew H, Kottom Theodore J
Abstract excerpt
Pneumocystis pneumonia remains the most common AIDS-defining opportunistic infection in people with HIV. The process by which Pneumocystis carinii constructs its cell wall is not well known, although recent studies reveal that molecules such as beta-1-3-glucan synthetase (GSC1) and environmental pH-responsive genes such as PHR1 are important for cell-wall integrity. In closely related fungi, a specific...
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