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Article

A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans.

Molecular microbiology - 1 Feb 2007

Nichols Connie B, Perfect Zahra H, Alspaugh J Andrew

Abstract excerpt

Pathogenic microorganisms must precisely regulate morphogenesis to survive and proliferate within an infected host. This regulation is often controlled by conserved signal transduction pathways that direct morphological changes in varied species. One such pathway, whose components include Ras proteins and the PAK kinase Ste20, allows the human fungal pathogen Cryptococcus neoformans to grow at high temperature....

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PMID: 17233829
DOI: 10.1111/j.1365-2958.2006.05566.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans.PMID 17233829Read ↗

Ras1 acts through duplicated Cdc42 and Rac proteins to regulate morphogenesis and pathogenesis in the human fungal pathogen Cryptococcus neoformans.Semantic proximity Read ↗

A Rac homolog functions downstream of Ras1 to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans.Semantic proximity Read ↗

Two CDC42 paralogues modulate Cryptococcus neoformans thermotolerance and morphogenesis under host physiological conditionsSemantic proximity Read ↗

Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformans The GenBank accession number for the RAS2 sequence of C. neoformans H99 is AF294349.Semantic proximity Read ↗

Molecular mechanisms of hypoxic responses via unique roles of Ras1, Cdc24 and Ptp3 in a human fungal pathogen Cryptococcus neoformans.Semantic proximity Read ↗

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