Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population.

doi:10.1038/nature04388

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Article

Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population.

Nature - 19 Jan 2006

Vignuzzi Marco, Stone Jeffrey K, Arnold Jamie J, Cameron Craig E, Andino Raul

Abstract excerpt

An RNA virus population does not consist of a single genotype; rather, it is an ensemble of related sequences, termed quasispecies. Quasispecies arise from rapid genomic evolution powered by the high mutation rate of RNA viral replication. Although a high mutation rate is dangerous for a virus because it results in nonviable individuals, it has been hypothesized that high mutation rates create a 'cloud' of...

Topics

Animals
Biological Evolution
Genome, Viral
HeLa Cells
Humans
Lethal Dose 50
Mice
Models, Biological
Mutagenesis
Organ Specificity
Phenotype
Poliovirus
Selection, Genetic
Virus Replication

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Identifiers

PMID: 16327776
DOI: 10.1038/nature04388
PMCID: PMC1569948

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