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Article

Brief but chronic increase in allopregnanolone cause accelerated AD pathology differently in two mouse models.

Current Alzheimer research - 1 Jan 2013

Bengtsson Sara K, Johansson Maja, Backstrom Torbjorn, Nitsch Roger M, Wang Mingde

Abstract excerpt

Previously, we have shown that chronic treatment with allopregnanolone (ALLO) for three months impaired learning function in the Swe/PS1 mouse model. ALLO is a neurosteroid, produced in the CNS and a GABAA receptor agonist. ALLO modulates the general inhibitory system in the CNS by enhancing the effect of GABA. Chronic treatment with other GABAA receptor active compounds, such as benzodiazepines, ethanol and...

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PMID: 23157375
DOI: 10.2174/1567205011310010006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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