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Article

Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects.

Biochimica et biophysica acta - 1 Aug 2010

Naylor Jennifer C, Kilts Jason D, Hulette Christine M, Steffens David C, Blazer Dan G, Ervin John F, Strauss Jennifer L, Allen Trina B, Massing Mark W, Payne Victoria M, Youssef Nagy A, Shampine Lawrence J, Marx Christine E

Abstract excerpt

The neurosteroid allopregnanolone has pronounced neuroprotective actions, increases myelination, and enhances neurogenesis. Evidence suggests that allopregnanolone dysregulation may play a role in the pathophysiology of Alzheimer's disease (AD) and other neurodegenerative disorders. Our prior dat...

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Identifiers

PMID: 20488256
DOI: 10.1016/j.bbalip.2010.05.006
PMCID: PMC2907131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20488256-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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