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Article

Allopregnanolone enhances the neurogenesis of midbrain dopaminergic neurons in APPswe/PSEN1 mice.

Neuroscience - 2 Apr 2015

Zhang P, Xie M Q, Ding Y-Q, Liao M, Qi S S, Chen S X, Gu Q Q, Zhou P, Sun C Y

Abstract excerpt

An earlier study has demonstrated that exogenous allopregnanolone (APα) can reverse the reduction of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra pars compacta (SNpc) of 3-month-old male triple transgenic Alzheimer's disease mouse (3xTgAD). This paper is focused on further c...

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Source

Identifiers

PMID: 25637494
DOI: 10.1016/j.neuroscience.2015.01.019

Genes

DCX
PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25637494-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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