Article
Challenging false discovery rate: a partition test based on p values in human case-control association studies.
Human heredity - 1 Jan 2012
Ott Jurg, Liu Zhe, Shen Yuanyuan
Abstract excerpt
BACKGROUND/AIMS: We consider the situation that multiple genetic variants are underlying a heritable trait and assume that each contributes to the trait only to a small degree. The aim is to develop a statistical test for disease association of these multiple variants. METHODS: We expect that p values resulting from a genome-wide case-control association analysis will fall into two classes: those reflecting true...
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