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Article

Detection of common single nucleotide polymorphisms synthesizing quantitative trait association of rarer causal variants.

Genome research - 1 Jul 2011

Takeuchi Fumihiko, Kobayashi Shotai, Ogihara Toshio, Fujioka Akihiro, Kato Norihiro

Abstract excerpt

Genome-wide association (GWA) studies have identified hundreds of common (minor allele frequency ≥5%) single nucleotide polymorphisms (SNPs) associated with phenotype traits or diseases, yet causal variants accounting for the association signals have rarely been determined. A question then raised is whether a GWA signal represents an "indirect association" as a proxy of a strongly correlated causal variant with...

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Identifiers

PMID: 21441355
DOI: 10.1101/gr.115832.110
PMCID: PMC3129254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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