Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of common single nucleotide polymorphisms synthesizing quantitative trait association of rarer causal variants.

Genome research - 1 Jul 2011

Takeuchi Fumihiko, Kobayashi Shotai, Ogihara Toshio, Fujioka Akihiro, Kato Norihiro

Abstract excerpt

Genome-wide association (GWA) studies have identified hundreds of common (minor allele frequency ≥5%) single nucleotide polymorphisms (SNPs) associated with phenotype traits or diseases, yet causal variants accounting for the association signals have rarely been determined. A question then raised is whether a GWA signal represents an "indirect association" as a proxy of a strongly correlated causal variant with...

Topics

Alleles
Apolipoproteins E
Computer Simulation
Databases, Genetic
Gene Frequency
Genetic Heterogeneity
Genome-Wide Association Study
Genotype
Humans
Linkage Disequilibrium
Models, Statistical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymorphism, Single Nucleotide

Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 21441355
DOI: 10.1101/gr.115832.110
PMCID: PMC3129254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of common single nucleotide polymorphisms synthesizing quantitative trait association of rarer causal variants.PMID 21441355Read ↗

Synthetic associations in the context of genome-wide association scan signals.Semantic proximity Read ↗

Rare variants create synthetic genome-wide associations.Semantic proximity Read ↗

Haplotype kernel association test as a powerful method to identify chromosomal regions harboring uncommon causal variants.Semantic proximity Read ↗

Rare variants, common markers: synthetic association and beyond.Semantic proximity Read ↗

Using synthetic datasets to better understand and explain health outcomes associated with common single nucleotide polymorphismsSemantic proximity Read ↗

Synthetic associations created by rare variants do not explain most GWAS results.Semantic proximity Read ↗

Potential synthetic associations created by epistasisSemantic proximity Read ↗

Joint rare variant association test of the average and individual effects for sequencing studies.Semantic proximity Read ↗

Comparison of single-marker and multi-marker tests in rare variant association studies of quantitative traits.Semantic proximity Read ↗

How many genetic variants remain to be discovered?Semantic proximity Read ↗

Distinguishing genetic correlation from causation across 52 diseases and complex traitsSemantic proximity Read ↗

Low-density lipoprotein receptor mutations generate synthetic genome-wide associations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.