Non-random sampling in human genetics: estimation of familial correlations, model testing, and interpretation.

doi:10.1002/sim.4780060511

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Article

Non-random sampling in human genetics: estimation of familial correlations, model testing, and interpretation.

Statistics in medicine - 1 Jan 2000

Chakraborty R, Hanis C L

Abstract excerpt

By choice or necessity, human geneticists and genetic epidemiologists often design studies that involve non-random sampling of clusters of individuals, and yet address hypotheses appropriate to the population as a whole. Failure to adjust for the non-randomness of data often leads to biased param...

Topics

Analysis of Variance
Data Interpretation, Statistical
Gene Frequency
Genetics, Medical
Humans
Models, Genetic
Phenotype
Regression Analysis
Sampling Studies

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