Non-random sampling in human genetics: estimation of familial correlations, model testing, and interpretation.

Abstract excerpt

By choice or necessity, human geneticists and genetic epidemiologists often design studies that involve non-random sampling of clusters of individuals, and yet address hypotheses appropriate to the population as a whole. Failure to adjust for the non-randomness of data often leads to biased parameter estimates and misspecification of predictive models that cause familial resemblance of traits. We develop an...

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