Article
A subregion-based burden test for simultaneous identification of susceptibility loci and subregions within.
Genetic epidemiology - 1 Oct 2018
Zhu Bin, Mirabello Lisa, Chatterjee Nilanjan
Abstract excerpt
In rare variant association studies, aggregating rare and/or low frequency variants, may increase statistical power for detection of the underlying susceptibility gene or region. However, it is unclear which variants, or class of them, in a gene contribute most to the association. We proposed a subregion-based burden test (REBET) to simultaneously select susceptibility genes and identify important underlying...
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