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Article

Functional characterization of protein variants encoded by nonsynonymous single nucleotide polymorphisms in MARC1 and MARC2 in healthy Caucasians.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2014

Ott Gudrun, Reichmann Debora, Boerger Cornelia, Cascorbi Ingolf, Bittner Florian, Mendel Ralf-Rainer, Kunze Thomas, Clement Bernd, Havemeyer Antje

Abstract excerpt

Human molybdenum-containing enzyme mitochondrial amidoxime reducing component (mARC), cytochrome b5 type B, and NADH cytochrome b5 reductase form an N-reductive enzyme system that is capable of reducing N-hydroxylated compounds. Genetic variations are known, but their functional relevance is unclear. Our study aimed to investigate the incidence of nonsynonymous single nucleotide polymorphisms (SNPs) in the mARC...

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PMID: 24423752
DOI: 10.1124/dmd.113.055202

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