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Sphere Culture of Murine Lung Cancer Cell Lines Are Enriched with Cancer Initiating Cells

13 Nov 2012

Abstract excerpt

Cancer initiating cells (CICs) represent a unique cell population essential for the maintenance and growth of tumors. Most in vivo studies of CICs utilize human tumor xenografts in immunodeficient mice. These models provide limited information on the interaction of CICs with the host immune system and are of limited value in assessing therapies targeting CICs, especially immune-based therapies. To assess this, a...

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PMID: 23152931
DOI: 10.1371/journal.pone.0049752

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