Article
In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity.
PloS one - 1 Jan 2013
Smart Chanel E, Morrison Brian J, Saunus Jodi M, Vargas Ana Cristina, Keith Patricia, Reid Lynne, Wockner Leesa, Askarian-Amiri Marjan, Amiri Marjan Askarian, Sarkar Debina, Simpson Peter T, Clarke Catherine, Schmidt Chris W, Reynolds Brent A, Lakhani Sunil R, Lopez J Alejandro
Abstract excerpt
Mammosphere and breast tumoursphere culture have gained popularity as in vitro assays for propagating and analysing normal and cancer stem cells. Whether the spheres derived from different sources or parent cultures themselves are indeed single entities enriched in stem/progenitor cells compared to other culture formats has not been fully determined. We surveyed sphere-forming capacity across 26 breast cell...
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