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Article

Identification of Tumor-Initiating Cells in a p53-Null Mouse Model of Breast Cancer

15 Jun 2008

Abstract excerpt

Using a syngeneic p53-null mouse mammary gland tumor model that closely mimics human breast cancer, we have identified, by limiting dilution transplantation and in vitro mammosphere assay, a Lin(-)CD29(H)CD24(H) subpopulation of tumor-initiating cells. Upon subsequent transplantation, this subpopulation generated heterogeneous tumors that displayed properties similar to the primary tumor. Analysis of biomarkers...

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PMID: 18559513
DOI: 10.1158/0008-5472.can-07-6353

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