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Cancer stem cells are underestimated by standard experimental methods in clear cell renal cell carcinoma

28 Apr 2016

Abstract excerpt

Rare cancer stem cells (CSC) are proposed to be responsible for tumour propagation and re-initiation and are functionally defined by identifying tumour-initiating cells (TICs) using the xenotransplantation limiting dilution assay (LDA). While TICs in clear cell renal cell carcinoma (ccRCC) appeared rare in NOD/SCID/IL2Rγ(-/-) (NSG) mice, xenografts formed more efficiently from small tumour fragments, indicating...

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PMID: 27121191
DOI: 10.1038/srep25220

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