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Article

Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells

30 Mar 2011

Abstract excerpt

The cancer stem cell (CSC) model proposes that tumors have a hierarchical organization in which only some cells indefinitely self-renew and thereby sustain tumor growth. In addition, the CSC model requires that tumor-initiating cells (TICs) be prospectively isolatable on the basis of their phenotype. Previous studies have suggested that serous ovarian cancer (SOC) conforms to the CSC model, but these used...

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PMID: 21451132
DOI: 10.1073/pnas.1005529108

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