Article
Gene size matters.
PloS one - 1 Jan 2012
Mirina Alexandra, Atzmon Gil, Ye Kenny, Bergman Aviv
Abstract excerpt
In this work we show that in genome-wide association studies (GWAS) there is a strong bias favoring of genes covered by larger numbers of SNPs. Thus, we state here that there is a need for correction for such bias when performing downstream gene-level analysis, e.g. pathway analysis and gene-set analysis. We investigate several methods of obtaining gene level statistical significance in GWAS, and compare their...
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