Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology.

Abstract excerpt

BACKGROUND: Despite earlier doubts, a string of recent successes indicates that if sample sizes are large enough, it is possible-both in theory and in practice-to identify and replicate genetic associations with common complex diseases. But human genome epidemiology is expensive and, from a strategic perspective, it is still unclear what 'large enough' really means. This question has critical implications for...

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