Quantitative intravital imaging in zebrafish reveals in vivo dynamics of physiological-stress-induced mitophagy

Abstract excerpt

ABSTRACT Mitophagy, the selective recycling of mitochondria through autophagy, is a crucial metabolic process induced by cellular stress, and defects are linked to aging, sarcopenia and neurodegenerative diseases. To therapeutically target mitophagy, the fundamental in vivo dynamics and molecular mechanisms must be fully understood. Here, we generated mitophagy biosensor zebrafish lines expressing mitochondrially...

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