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Article

SOX6 blocks the proliferation of BCR-ABL1+ and JAK2V617F+ leukemic cells

4 Mar 2019

Abstract excerpt

Abstract SOX6 is a HMG-box transcription factor expressed in a wide range of tissues. Recent data show that SOX6 expression is altered in different cancers, in the majority of cases being downregulated. To date, no data are available about SOX6 role in hematological malignancies. Here we demonstrate that SOX6 overexpressing BCR-ABL1+ B-ALL cells are unable to promote leukemia in a mouse model. Starting from this...

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PMID: 30833651
DOI: 10.1038/s41598-019-39926-4

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