Article
Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia.
Channels (Austin, Tex.) - 1 Jan 2000
Jiang Dawei, Jones Peter P, Davis Darryl R, Gow Robert, Green Martin S, Birnie David H, Chen S R Wayne, Gollob Michael H
Abstract excerpt
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmogenic disease that manifests as syncope or sudden death during high adrenergic tone in the absence of structural heart defects. It is primarily caused by mutations in the cardiac ryanodine receptor (RyR2). The mechanism by which these mutations cause arrhythmia remains controversial, with discrepant findings related to the role of the...
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