Article
In situ confocal imaging in intact heart reveals stress-induced Ca(2+) release variability in a murine catecholaminergic polymorphic ventricular tachycardia model of type 2 ryanodine receptor(R4496C+/-) mutation.
Circulation. Arrhythmia and electrophysiology - 1 Aug 2012
Chen Biyi, Guo Ang, Gao Zhan, Wei Sheng, Xie Yu-Ping, Chen S R Wayne, Anderson Mark E, Song Long-Sheng
Abstract excerpt
BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia is directly linked to mutations in proteins (eg, type 2 ryanodine receptor [RyR2](R4496C)) responsible for intracellular Ca(2+) homeostasis in the heart. However, the mechanism of Ca(2+) release dysfunction underlying catecholaminergic polymorphic ventricular tachycardia has only been investigated in isolated cells but not in the in situ...
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