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Article

IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis

28 Apr 2020

Abstract excerpt

IL-36R signaling plays an important role in the pathogenesis of psoriasis. We ought to assess the specific function of IL-36R in keratinocytes for the pathology of Aldara-induced psoriasis-like dermatitis. Il36rΔK mice presenting deletion of IL-36R in keratinocytes were similarly resistant to Aldara-induced ear inflammation as Il36r−/− mice, but acanthosis was only prevented in Il36r−/− mice. FACS analysis...

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PMID: 32345660
DOI: 10.26508/lsa.202000688

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