Article
Rap1a deficiency modifies cytokine responses and MAPK-signaling in vitro and impairs the in vivo inflammatory response.
Cellular immunology - 1 Jan 2000
Dorn Annette, Zoellner Anna, Follo Marie, Martin Stefan, Weber Felix, Marks Reinhard, Melchinger Wolfgang, Zeiser Robert, Fisch Paul, Scheele Jürgen S
Abstract excerpt
Rap1, which is closely related to ras, plays a key role in T-cell receptor (TCR)-signaling. TCR-stimulation without costimulation leads to constitutively activated rap1, which may mediate T-cell anergy via inhibition of ras-dependent induction of extracellular signal-regulated kinases (ERK). This activation is mediated by a second protein kinase b-Raf. Rap1-GTP is thought to activate ERK in a ras-independent...
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