Article
Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors.
Hepatology (Baltimore, Md.) - 1 Feb 2014
Ramirez Santseharay, Li Yi-Ping, Jensen Sanne B, Pedersen Jannie, Gottwein Judith M, Bukh Jens
Abstract excerpt
UNLABELLED: Hepatitis C virus (HCV) is a genetically diverse virus with multiple genotypes exhibiting remarkable differences, particularly in drug susceptibility. Drug and vaccine development will benefit from high-titer HCV cultures mimicking the complete viral life cycle, but such systems only exist for genotypes 1a and 2a. We developed efficient culture systems for the epidemiologically important genotype 2b....
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