Article
Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 2013
Alvarez-Madrazo Samantha, Mackenzie Scott M, Davies Eleanor, Fraser Robert, Lee Wai-Kwong, Brown Morris, Caulfield Mark J, Dominiczak Anna F, Farrall Martin, Lathrop Mark, Hedner Thomas, Melander Olle, Munroe Patricia B, Samani Nilesh, Stewart Paul M, Wahlstrand Björn, Webster John, Palmer Colin N A, Padmanabhan Sandosh, Connell John M
Abstract excerpt
The locus encompassing the corticosteroidogenic genes CYP11B2 and CYP11B1 is of potential importance in essential hypertension. We analyzed the association of polymorphisms at this locus with risk of essential hypertension, using 2 white case-control collections for discovery (n=3340) and confirmation (n=2929). Single-marker and haplotype analyses were performed, with the CYP11B2 Intron 2 Conversion polymorphism...
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