Understanding the basis of a class of paradoxical mutations in AraC through simulations.

doi:10.1002/prot.24207

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Article

Understanding the basis of a class of paradoxical mutations in AraC through simulations.

Proteins - 1 Mar 2013

Damjanovic Ana, Miller Benjamin T, Schleif Robert

Abstract excerpt

Most mutations at position 15 in the N-terminal arm of the regulatory protein AraC leave the protein incapable of responding to arabinose and inducing the proteins required for arabinose catabolism. Mutations at other positions of the arm do not have this behavior. Simple energetic analysis of the interactions between the arm and bound arabinose do not explain the uninducibility of AraC with mutations at position...

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PMID: 23150197
DOI: 10.1002/prot.24207
PMCID: PMC3557760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.