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Article

Impacts of mutations on dynamic allostery of adenylate kinase.

The Journal of chemical physics - 21 Jul 2021

Song Haoyu, Wutthinitikornkit Yanee, Zhou Xiaozhou, Li Jingyuan

Abstract excerpt

Escherichia coli adenylate kinase (AK) is composed of CORE domain and two branch domains: LID and AMP-binding domain (AMPbd). AK exhibits considerable allostery in a reversible phosphoryl transfer reaction, which is largely attributed to the relative motion of LID and AMPbd with respect to CORE. Such an allosteric conformational change is also evident in the absence of ligands. Recent studies showed that the...

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PMID: 34293874
DOI: 10.1063/5.0053715

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