Article
Neuroendocrine phenotype alteration and growth suppression through apoptosis by MK-2206, an allosteric inhibitor of AKT, in carcinoid cell lines in vitro.
Anti-cancer drugs - 1 Jan 2013
Somnay Yash, Simon Kevin, Harrison April D, Kunnimalaiyaan Selvi, Chen Herbert, Kunnimalaiyaan Muthusamy
Abstract excerpt
Carcinoids are neuroendocrine malignancies characterized by their overproduction of various bioactive hormones that lead to the carcinoid syndrome. We have shown previously that AKT serves as a key regulator of growth and phenotypic expression of tumor markers in carcinoids by the genetic depletion of AKT expression. However, no small-molecule inhibitor of AKT kinase activity has been developed until recently....
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