Article
Inhibition of phosphatidylinositol 3-kinase/Akt signaling suppresses tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumors.
Annals of surgical oncology - 1 Oct 2009
Pitt Susan C, Chen Herbert, Kunnimalaiyaan Muthusamy
Abstract excerpt
BACKGROUND: Overactivation of PI3K/Akt signaling facilitates tumor proliferation in several cancers. We have shown that various signal transduction pathways promote tumorigenesis in carcinoid tumors, which exhibit endogenously high levels of active, phosphorylated Akt. Therefore, we hypothesized that inhibition of the PI3K/Akt pathway would suppress carcinoid tumor cell growth and neuroendocrine (NE) marker...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.