Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Berberine inhibits the malignant cell phenotype by inactivating PI3K/AKT/mTOR signaling in laryngeal squamous cell carcinoma.

Histology and histopathology - 1 Nov 2024

Lin Ling, Chen Zhen, Huang Ping, Chen Wei, Zou Zhefei, Zheng Yexian, He Chang, Gu Xiang, Yu Dan, Zhang Qiong

Abstract excerpt

BACKGROUND: Berberine is an active compound found in different herbs used in Chinese medicine and is well-known for its potential anticancer properties. The study aimed to figure out the role of berberine in regulating the malignant behavior of laryngeal squamous cell carcinoma (LSCC) cells. METHODS: LSCC cell lines (SNU-899 and AMC-HN-8) were treated with different concentrations of berberine (0-200 μM) to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Laryngeal Neoplasms

Share to Neoplasm Invasiveness

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Squamous Cell Carcinoma of Head and Neck

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 38712806
DOI: 10.14670/HH-18-753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Berberine inhibits the malignant cell phenotype by inactivating PI3K/AKT/mTOR signaling in laryngeal squamous cell carcinoma.PMID 38712806Read ↗

Cancer Pathways Targeted by Berberine: Role of microRNAsSemantic proximity Read ↗

Anlotinib inhibits the development of esophageal squamous cell carcinoma by regulating the PI3K/AKT signaling pathwaySemantic proximity Read ↗

Berberine-targeted miR-21 chemosensitizes oral carcinomas stem cellsSemantic proximity Read ↗

Cell-specific pattern of berberine pleiotropic effects on different human cell linesSemantic proximity Read ↗

EGFR–PI3K–AKT–mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapySemantic proximity Read ↗

Berberine induces apoptosis and arrests the cell cycle in multiple cancer cell linesSemantic proximity Read ↗

The Curcumin Analog (PAC) Has Anti-Oral Cancer Properties Through Impairing Pro-Survival Signaling Pathways and Activating the Cell Death Processes Apoptosis and AutophagySemantic proximity Read ↗

Berberine Inhibited the Growth of Thyroid Cancer Cell Lines 8505C and TPC1Semantic proximity Read ↗

Molecular mechanisms of apoptosis and autophagy elicited by combined treatment with oridonin and cetuximab in laryngeal squamous cell carcinomaSemantic proximity Read ↗

Targeting AKT with Oridonin Inhibits Growth of Esophageal Squamous Cell Carcinoma In Vitro and Patient-Derived Xenografts In VivoSemantic proximity Read ↗

Curcumin suppresses the malignant phenotype of laryngeal squamous cell carcinoma through downregulating E2F1 to inhibit FLNA.Semantic proximity Read ↗

Nerolidol induced apoptosis in human laryngeal cancer cells (Hep 2) through activation of ROS and mitochondrial-mediated pathway: An in vitro and in silico studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.